Home » The HLA-DR Gene and Mold Sensitivity

The HLA-DR Gene and Mold Sensitivity

by Amanda Demsky
HLA genetics and mold

Why is it that mold affects each person differently? How come some people present no symptoms at all or they tend to recover from symptoms as soon as the source of the mold is eradicated, while others develop chronic health problems from a single encounter with mold? The answer lies in a person’s genetic predisposition toward mold illness, which stems from the HLA-DR gene.


Note to readers: The particulars behind HLA-DR’s problematic effect on the immune system require delving into expansive details of the Major Histocompatibility Complex (MHC) in humans, as well as the definition and functions of various molecules and proteins—such as antigens, peptides, and T-cell receptors, to name a few—in relation to the pituitary and hypothalamic axis, and the immune system as a whole. For those of you who are biology buffs, I apologize for oversimplifying things. And, for those of you who dreaded every day of high school biology, well, you’re welcome. Without further ado, let’s jump right in and butcher a very complex problem with a very modest explanation.

What is the HLA-DR Gene?

The Human Leukocyte Antigen is a protein—or marker—that is found on most cells in your body. Your immune system uses these markers to recognize which cells belong in your body and which cells do not. When an antigen is presented correctly to a T-cell receptor, for example, the appropriate immune response is given and foreign threats can be destroyed or removed from the body. This is an imperative function in the defense against biotoxins—toxic substances that have an organic origin, such as mycotoxins (fungi—yeast and mold), zootoxins (animals), and phytotoxins (plants).

When a person carries the HLA-DR gene, however, they are genetically susceptible to biotoxic illnesses because the HLA-DR causes a misprocessing of antigens, which inhibits the immune system from reacting correctly to infection and toxins.

HLA-DR and Mold Illness

Fungal triggers of the HLA-DR are often the most devastating to health. Over 36 different diseases can result from an HLA-DR carrier’s exposure to mold. This is because HLA-DR(BQ) inhibits the immune system from recognizing mycotoxins as a threat, thus impeding it from producing antibodies that are needed for deactivating and removing mold toxins. Because of this, mycotoxins and aflatoxins are stored throughout the body (namely in the “fatty” regions, such as the brain) while their negative effects go undiagnosed or incorrectly treated by the immune system for weeks, months, years, or even a lifetime.

Because the mycotoxins are misprocessed and stored, the immune system will overreact to toxic and non-toxic materials. It can lose its ability to correctly differentiate between “self” and “foreigner,” often misfiring and wreaking more havoc on the body than the mycotoxins would have done on their own. In short, HLA-DR and mold illness are synonymous with autoimmune disease and disorder.

When a group is exposed to mold, the HLA-DR carriers will be the first to experience an immune response and the last to recover—if they recover at all. Rarely does the HLA-DR victim suffer only the first line of defense markers for mold sickness, such as:

  • watering, irritated eyes
  • red eyes
  • hives
  • sneezing
  • runny nose
  • nausea
  • vomiting
  • burning sensations in airways
  • a tightening in the chest
  • cough
  • nuances of asthma
  • nosebleed
  • fever
  • numbness/tingling
  • a long, painful headache

Instead, they’re more likely to experience many of those symptoms long term and more intensely than non-carriers who were exposed to the same mold for the same duration of time. In addition, they’re now more susceptible to other chronic and seemingly-unrelated illnesses, disorders, and diseases (because HLA-DR permits the storing of mold toxins that eventually destroy neurons in the brain and disrupt hormone production):

Acne (cystic, as well)



Autoimmune diseases

Balkan nephropathy (a type of kidney disease)

Brain disorders

Bronchitis (repeat occurrences)

Celiac disease (severe gluten intolerance that puts the small intestine at risk)

Chronic sinus congestion

Colitis (inflammation of the colon lining)

Dry skin (dull, ashy-looking skin, cracked heels, chapped lips)

Epstein-Barr Virus (“Mono”)

Gastrointestinal issues

Graves Disease (i.e. hyperthyroidism)

Gum disease

Hashimoto’s Disease (autoimmune disease that damages the thyroid gland)

Heart Disease

Hepatocellular carcinoma (primary type of liver cancer)

Histamine intolerance

Insulin resistance

Irritable Bowel Syndrome (IBS)

Joint-connective tissue disorders

Kashin-Beck disease (death of bone and joint cartilage growth plates, resulting in disruption of normal growth in children and adolescents)

Lupus (inflammatory autoimmune disease that attacks the body’s healthy tissues and organs)

Lyme disease

Memory problems (short term)

Multiple Sclerosis

Parkinson’s Disease


Respiratory infections


Reye’s syndrome (swelling in the liver and brain—mostly occurs in children and teenagers)

Rheumatological disorders (r. arthritis)

Scalp issues (lesions, rashes, acne, abscesses, cysts)


Sjogren’s Syndrome

“Static shock” occurrences more frequent (caused by higher salt content due to dehydration)

Thirst (unquenchable)

Thyroid dysfunction

Weight gain (sudden)

Worsening vision

And so much more…

What Are the Chances That You Are a Carrier of the HLA-DR Gene?

So far, it’s been established that roughly 25% of the population is a carrier (and sufferer) of the HLA-DR gene. That’s over 80 million people in the United States alone! New research, however, is emerging that indicates that the initial assessment could be drastically inaccurate. Genetic studies on certain populations now suggest that the true number could be anywhere between 40% and 60% worldwide!

In one study conducted on four different populations, including an isolated Hutterite population, it was determined that, while those working regularly in agriculture showed mildly increased cases of mold sensitivity and asthmatic symptoms, the predisposition toward mold sensitivity and related allergens/illnesses, certainly appears to be genetic and estimated to affect around 60% of the population. It was originally assumed that isolated “inbred” groups (closely and distantly related) were more likely to pass on these susceptibility genes, but after expanding their research to include several “outbred” groups from large, multi-racial cities, they discovered that cases of genetic mold sensitivity only dropped by 10 to 20% (due to gene variance). In other words, this alarmingly high percentage of genetic mold sensitivities is not dependent on tight-knit communities of distant cousins, nor is it dependent on whether or not the lifestyle centers on agriculture. Even the most genetically-diverse populations teeter between 40% and 60% (as mentioned before).

Is There Anything Good About Having the HLA-DR Gene?

Several health professionals and genetics experts would argue that carriers of the HLA-DR mold-sensitivity gene act as canaries for the health and safety of the population at large.

Mold affects everyone, even those who aren’t genetically vulnerable to it. Some mold victims seem to be asymptomatic, but given enough exposure time to a toxic mold, they’ll eventually succumb to a mold-related illness or disorder. Mold is not always growing where it is visible to the naked eye, especially in older buildings. Centuries-old homes, apartments, and municipal buildings, for instance, often have deep rot and mold infestation within the inner structures. This is why, in a sense, it is good to have HLA-DR carriers because their immediate immune response to mold could act as a warning sign to others in a home or workspace that mold is present. (Of course, this is assuming the carrier and others are able to diagnose the symptoms correctly.)

What Can Be Done if You are a Carrier of HLA-DR?

While it does leave the immune system vulnerable to biotoxins, it doesn’t have to be a death sentence. The most important point to take home, regarding HLA-DR, is that it is genetic, which means that, if you are a carrier, the effects of the HLA-DR gene will permanently govern the way you live your life. While your spouse, friends, or coworkers may experience a restoration of full health once mold exposure is diminished, you will have to actively encourage your body to heal from mold illness with lifestyle choices, such as an anti-fungal diet or an anti-fungal supplement routine, in addition to detoxing exercise and adequate sleep.

In other words, HLA-DR carriers, unlike non-carriers, will have to actively pursue a course of treatment and live a specific lifestyle that promotes biotoxin shedding.

Testing for the HLA-DR Gene

WARNING: If you believe you are a carrier of the HLA-DR gene, please do NOT pursue testing through commercial DNA testing agencies, such as 23andMe, AncestryDNA, National Geographic Geno 2.0, or any other like service. These agencies are not required by law to follow HIPAA guidelines, which means they have the right to sell your genetic panel to insurance companies. This could result in a denial of insurance coverage or a rise in the cost of insurance should you prove to have pre-existing conditions or medical predispositions.

For the most part, testing for the HLA-DR gene is not necessary when determining treatment options for the various illnesses and disorders encouraged by it. However, it might be helpful to a potential carrier if they obtain proof of their genetic susceptibility to mold sickness for the purpose of cautiously planning their lifestyle and living conditions, as well as establishing medical or legal recourse in the case of inept diagnoses and property negligence.

Unless you are able to convince your doctor to see the HLA-DR genetic panel as a necessity in their diagnosis and treatment, be aware that insurance will not cover the blood tests or the reading of the test results. In general, prices range between $300 and $400 if you must order the testing yourself.

Blood testing for HLA-DR is available through the LabCorp and Life Extension laboratories.

Important Note: Those familiar with the Quest Diagnostics laboratory should not confuse their HLA blood test for the HLA-DR mold illness susceptibility panel. A standard HLA blood test will only yield results in terms of tissue donor matching. Quest Diagnostics does offer the C3A and C4A tests that determine whether a person has been exposed to mold recently or long term, but those tests will not shed light on underlying genetic susceptibilities and are only useful in certain scenarios.


Unbeknownst to many, the HLA-DR gene affects between 40% and 60% of the world’s population. It accounts for a greater susceptibility to yeast and mold illnesses, as well as autoimmune diseases.

Carriers of the HLA-DR gene are prone to develop chronic health issues involving systemic inflammation, whether the cause is mold, Lyme’s, gluten, or countless other catalysts. Not only does HLA-DR make a carrier vulnerable to chronic biotoxin disease, it also makes detoxification and healing extremely difficult. Thankfully, there is hope with a strict adherence to preventative and detoxifying protocols.

For more information regarding mold, mold prevention, and mold solutions, please check out the rest of MoldBlogger.com.

Article by Amanda Demsky from the MoldBlogger team.

Want The Inside Scoop?

Related Articles


Rom From Los Angeles October 20, 2019 - 12:04 pm

I work with a mold restoration company and this is indeed a very nice blog

cindy August 9, 2020 - 4:20 pm

I knew I was allergic to mold. I avoided it. My husband accidentally mycotoxin poisoned me with back up coffee maker on Sept 2 2019 and my life was profoundly changed. I survived anaphylaxis but CIRS/ME/CDR is HORRID. Cannot walk uphill, carry wt, brain ruined, in lots of pain and after almost a year of many detox protocols and treatments I still fail VCS test. A weak zombie. I used to be strong , athletic and bright. WIFI, EMFs etc agitate the mold and they make stronger mycotoxins. I continue treatments (none are very good in BAD HLA types) We need research for better options.

Bobbi Van Eman November 27, 2020 - 10:02 pm

Good article. I like your succinct explanation of the hla-dr gene in accordance with mold illness. I have “Toxic Mold Illness” & CIRS. It is a nightmare ! I am taking a multitude of supplements just to survive. Dr. Shoemsker & others have done their best to come up with a protocol to help alleviate some of the suffering that we victims endure but no one seems to be able to discover a cure…epigenetics maybe ? The last 5 yrs. of my life have been devoted to researching anything I could get my hands on to try to survive. I am, frankly, very tired of it all & sometimes feel like giving up. The only thing that keeps me encouraged is my faith in God & His healing powers. I live in a very wet, moldy & chemically polluted (from steel mills) area. I have moved 20 times to try to find safe, suitable, breathable, low mold housing to no avail. I pray constantly for relief from this horrific form of personal hell & wisdom from the Almighty as to which avenue to take next. Perhaps 2021 will be breakthrough year for us mold victims. God can create rivers in the desert & make a way where there seems to be no way. We must believe & trust in Him. Until then, God bless everyone & I am praying for everyone with this illness which is from the pits of the abyss. By Jesus’s stripes we are healed ! ?

Bobbi Van Eman November 27, 2020 - 10:12 pm

I did not intend to put a question mark at the end of … By Jesus’s stripes we are healed ! I tapped on the praying hands symbol, not a question mark. It was a statement, not a question. I don’t know how the question mark got there. I know we have been healed by the Blood of the Lamb (Isaiah & Peter). satan is doing his best to attack the Word of God in any way he can. Back to hell with you, beelzebub. Your time is short ! ?

Ant December 1, 2020 - 5:04 am

Hi can you please link any and all research that places the HLA-DR as a mold susceptible gene other then shoemakers work.

Lauren January 2, 2021 - 2:03 pm

To those who suspect mold in their home, I’d like to suggest placing Snake Plants throughout. Not only do they create oxygen day and night, they’re also known for fighting mold. I noticed an immediate difference in air quality when I put one in my bedroom. May God bless you!

krystle January 3, 2021 - 1:03 pm

Thanks for suggestion! Plants can be a great way to help filter indoor air!

Tony K February 7, 2021 - 9:41 pm

Are the HLA-DR genes for Lyme and Mold exclusive for each condition? Or can they prone to the other one?

i.e could someone with two alleles for Borrelia suffer CIRS from toxic mold? Without tick bite.

Horizon February 8, 2021 - 3:01 pm

I am very grateful for this website. I learned I have a HLA-DR antigen back in my 30s. Did research to better understand, but not much understanding was available. Then, here recently, I learned of this new mold hypersensitivity testing. And so, I had the test performed. My results confirmed my mold hypersensitivity and my specific genotype. Then, with my specific genotype being known, I was able to acquire more insight and more clarity. I was amazed, for I had many past medical problems that neither I or my physicians knew were connected to the HLA-DR foundation. Thank you for making this post.

krystle February 12, 2021 - 3:44 pm

Thank you for sharing! What was the new mold hypersensitivity testing you were able to do?

Barb March 1, 2021 - 11:22 am

Do you know of a resource to order the HLA-DR test? Life Extension used to do the blood test but now do a cheek swab and for some reason they can’t ship to PA….


Leave a Comment

Want The Inside Scoop?